A PR specialist refuses to market a car called a "Howard" - a colossal error that loses him a billion and makes him a national joke. He loses his hair, shaves his beard, takes a new name, and moves to Martha's Vineyard. Jump ten years: "Rolly" is a popular local whose sangfroid evaporates when the Howard's inventor moves to the island. Rolly, his old self unrecognizable, hatches a plan to rid the island of his nemesis; he also decides to woo the billionaire's wife. Fellatio, a former girlfriend, a woman who's lost weight, her boyfriend, the band Chicago, a menacing Chechen, a bus load of ill children, and a pair of ne'er-do-wells with experience with explosives figure in the story.

Left on the doorstep of an orphanage managed by nuns, newborns Moe, Larry and Curly grow up finger-poking, nyuk-nyuk-nyuking and woo-woo-wooing their way to uncharted levels of knuckleheaded misadventure. Now their childhood home may have to close due to financial difficulties. But Moe, Larry and Curly employed as the foster home's inept maintenance men, are determined to come to the rescue. Only the Three Stooges could become embroiled in an oddball murder plot - while stumbling into starring roles in a phenomenally successful reality television show.

Bob and Walt Tenor are twin brothers, who not only share a passion for life, but also a liver. Thanks to their teamwork, being conjoined twins is not a handicap to them. But, when Walt's dreams of stardom of acting on the screen and Bob's shyness clashes, they both begin to fall out. This doesn't help when Bob's Internet girl arrives in town, unaware of their handicap, and when Walt gains his own TV show with Cher.

After one too many run ins with the law, a punk teenager from a working class background is sent to prep school by his frustrated dad, and learns a thing or two.

Charlie is a Rhode Island state trooper with a multiple personalities. He is otherwise mild-mannered and non confrontational until somebody or something pushes him a little too far. That's when his maniacal alter-ego, Hank, takes over. Charlie is assigned on a routine mission to return alleged fugitive Irene back to upstate New York, but they wind up on the run from corrupt police officers. And their escape would be a lot simpler on everybody involved if Hank didn't keep stepping in at the most inopportune times....

Eddie is forty, owns a sporting-goods store, and is still single. After watching his ex-fiancée walk down the aisle, he meets Lila, an environmental researcher, who seems too good to be true. Pressured by his father and best friend, Eddie pops the question and marries Lila after only 6 weeks. However, as he almost instantly discovers, his new bride is a nightmare with more baggage than he can handle. She's immature, foolish, a monster in bed, owes a tremendous amount of money to various sources, and as it turns out, is only a volunteer and doesn't actually have a job. While on their honeymoon in Cabo, Eddie meets Miranda, a down-to-earth lacrosse coach who is visiting with her family. Sparks fly, and Eddie falls for her. Now comes the tricky part of breaking off his marriage to crazy Lila, all while keeping the truth from Miranda about why he's in Cabo in the first place...